2019年新型冠状病毒疫情爆发后，澳门特区政府为加强疫情防控措施于同年3月实施了出入境新规定，根据最新消息显示：，- 持有效旅游签注的旅客在入境时需进行核酸检测并等待结果呈阴性后方可进入；若检测阳性则须接受隔离治疗或居家医学观察等安排（具体时间视情况而定），同时对于来自高风险地区的游客还需提供健康码和行程单等相关文件以备查验及登记信息使用。（自5月起）

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